Beauty Encyclopedia›Acetyl Hexapeptide-3

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Acetyl Hexapeptide-3

Also known as: Argireline, Botox-like peptide, Acetyl Hexapeptide-8

Generally SafepeptideEWG: 1

A neurotransmitter-inhibiting peptide that relaxes expression lines without needles.

How it works

Acetyl Hexapeptide-3 (also known as Argireline) is a fragment of SNAP-25, a protein involved in neurotransmitter release. It inhibits the catecholamine release that triggers facial muscle contractions, producing a mild relaxing effect on expression lines — particularly around the eyes and forehead. The effect is modest and localised; it does not penetrate deeply enough to affect motor neurons systemically.

Concentration note

Clinical data at 10%. Most products use 5–10%.

Best for

Expression linesForehead wrinklesCrow's feetNon-invasive anti-ageing

Commonly found in

Eye serumsAnti-wrinkle creamsExpression line treatments

✅ Pairs well with

Hyaluronic AcidPalmitoyl Pentapeptide-4Niacinamide

Safety & restrictions

No known safety concerns. Topical application does not produce systemic effects.

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For informational purposes only. Not medical advice. Consult a dermatologist for personalised guidance.